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Kolster Methods rotigotine
The flow diagram of selecting <t>Rotigotine-related</t> AEs from FAERS database
Rotigotine, supplied by Kolster Methods, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rotigotine/rotigotine/pmc11956487-274-12-19
Average 90 stars, based on 1 article reviews
rotigotine - by Bioz Stars, 2026-09
90/100 stars

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1) Product Images from "Rotigotine safety in real-world settings: a pharmacovigilance study using FAERS data"

Article Title: Rotigotine safety in real-world settings: a pharmacovigilance study using FAERS data

Journal: BMC Pharmacology & Toxicology

doi: 10.1186/s40360-025-00911-5

The flow diagram of selecting Rotigotine-related AEs from FAERS database
Figure Legend Snippet: The flow diagram of selecting Rotigotine-related AEs from FAERS database

Techniques Used:

Clinical characteristics of reports with  rotigotine  from the FAERS database
Figure Legend Snippet: Clinical characteristics of reports with rotigotine from the FAERS database

Techniques Used:

Time to onset of  Rotigotine-associated  adverse events and Weibull distribution analysis
Figure Legend Snippet: Time to onset of Rotigotine-associated adverse events and Weibull distribution analysis

Techniques Used:

The signal strength of AEs related to  rotigotine  at the SOC level in the FAERS database was detected by four algorithms
Figure Legend Snippet: The signal strength of AEs related to rotigotine at the SOC level in the FAERS database was detected by four algorithms

Techniques Used:

Signal Strength of top20 AEs of Rotigotine at the PT Level in FAERS Database
Figure Legend Snippet: Signal Strength of top20 AEs of Rotigotine at the PT Level in FAERS Database

Techniques Used:

The top 30 most frequent adverse events for  rotigotine  excluding common medication co-usage at the PT level from FAERS data
Figure Legend Snippet: The top 30 most frequent adverse events for rotigotine excluding common medication co-usage at the PT level from FAERS data

Techniques Used:

The top 30 signal strength of adverse events of  rotigotine  ranked by the number of case reports at the PTs level in FAERS database
Figure Legend Snippet: The top 30 signal strength of adverse events of rotigotine ranked by the number of case reports at the PTs level in FAERS database

Techniques Used:

Related Articles

other:

Article Title: Dopaminergic Therapy for Restless Legs Syndrome/Willis-Ekbom Disease.
Article Snippet: Several dopamine agonists are approved for the treatment of restless legs syndrome (RLS)/WillisEkbom disease (WED).. Although they have similar profiles, there are specific instances that may favor one more than another.. Sinemet can be used for short-term intermittent circumstances of forced immobilization, such as airplane flights.

Article Title: Rotigotine safety in real-world settings: a pharmacovigilance study using FAERS data
Article Snippet: Concurrently, in a German clinical trial assessing the efficacy and tolerability of rotigotine for treating RLS led by Karin Stiasny-Kolster et al., a total of 84 skin reactions were documented among 66 (9.6%) of the patients.

Article Title: Rotigotine in the treatment of primary restless legs syndrome: A meta-analysis of randomized placebo-controlled trials.
Article Snippet: Jun DING (丁 君), Wei FAN (范 威), Hong-hui CHEN (陈红辉), Peng YAN (闫 鹏) , Sheng-gang SUN (孙圣刚), Jin ZHENG (郑 瑾) Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China Department of Breast Surgery, Hubei Cancer Hospital, Wuhan 430079, China Wuhan First Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

Article Title: Rotigotine transdermal patch in the treatment of Parkinson's disease and restless legs syndrome.
Article Snippet: Dopamine agonists are effective in delaying levodopa-induced dyskinesia in early Parkinson’s disease (PD) and reducing motor fluctuations in advanced PD.. Rotigotine, a novel dopamine receptor agonist, improves motor function in both early and advanced PD using a transdermal route of administration.. A smaller, but convincing body of data, supports its ability to ameliorate the symptoms of restless legs syndrome as well.

Article Title: Rotigotine transdermal system: developing continuous dopaminergic delivery to treat Parkinson's disease and restless legs syndrome.
Article Snippet: In 684 patients with moderate-to-severe RLS (72% female; mean age 65.6 years), Stiasny-Kolster et al. evaluated rotigotine treatment in a routine clinical practice setting in Germany over 3 months.111 In this clinical-practice study, 55% of patients (233/424) were switched directly or overnight to rotigotine monotherapy from previous monotherapy with levodopa (50.1% (202/403)), pramipexole (23.8% (96/403)), or ropinirole (10.2% (41/403)) without downtitration.

Article Title: Dopamine agonists for the treatment of restless legs syndrome
Article Snippet: [ Google Scholar ] Stiasny‐Kolster 2004b {published and unpublished data} Stiasny‐Kolster K, Kohnen R, Schollmayer E, Moller JC, Oertel WH, Rotigotine Sp 666 Study G. Patch application of the dopamine agonist rotigotine to patients with moderate to advanced stages of restless legs syndrome: a double‐blind, placebo‐controlled pilot study .

Clinical Proteomics:

Article Title: Patch application of the dopamine agonist rotigotine to patients with moderate to advanced stages of restless legs syndrome: a double-blind, placebo-controlled pilot study.
Article Snippet: Efficacy and safety of the dopamine agonist rotigotine (RTG) was investigated in patients with moderate to severe idiopathic restless legs syndrome (RLS), including daytime symptoms.. Three fixed doses of rotigotine (1.125 mg, 2.25 mg, and 4.5 mg) and placebo were applied by patches (size, 2.5 cm per 1.125 mg) in a double-blind, randomized, parallel-group, multicenter, 1-week, proof-ofprinciple trial.. The primary efficacy measure was the total score on the International Restless Legs Syndrome Scale (IRLS).

Article Title: The use of rotigotine in the treatment of restless legs syndrome
Article Snippet: .. Clinical trials The efficacy of rotigotine in treating RLS was first demonstrated by a study conducted by Stiasny-Kolster and colleagues in 2004 [ Stiasny-Kolster et al. 2004b ]. ..



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The flow diagram of selecting <t>Rotigotine-related</t> AEs from FAERS database
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Synthesis and characterization of Rotigotine-loaded nanoparticles (RT-NPs). (a) Scheme for showing the preparative procedures for RT-NPs. The different mass ratio of rotigotine to PEG- b -PPG- b -PEG (average Mn 12,000) are set as seven groups, with the reaction volume hold constant in each group, the polymer maintaine a consistent concentration at 10 mg/mL in (b) and rotigotine concentration is fixed around 1 mg/mL in (c). (d) The mass ratio, reaction volume, and polymer concentration are consistent with (b) except for the use of polymer with a lower molecular weight (Mn 8400). (e) Entrapment efficiency of RT-NPs in (b)-(d).

Journal: Fundamental Research

Article Title: Intranasal delivery of rotigotine to the brain for treating Parkinson’s disease

doi: 10.1016/j.fmre.2025.02.004

Figure Lengend Snippet: Synthesis and characterization of Rotigotine-loaded nanoparticles (RT-NPs). (a) Scheme for showing the preparative procedures for RT-NPs. The different mass ratio of rotigotine to PEG- b -PPG- b -PEG (average Mn 12,000) are set as seven groups, with the reaction volume hold constant in each group, the polymer maintaine a consistent concentration at 10 mg/mL in (b) and rotigotine concentration is fixed around 1 mg/mL in (c). (d) The mass ratio, reaction volume, and polymer concentration are consistent with (b) except for the use of polymer with a lower molecular weight (Mn 8400). (e) Entrapment efficiency of RT-NPs in (b)-(d).

Article Snippet: Dichloromethane was purchased from Chinasun Specialty Products Co., Ltd. Poly (ethylene glycol)-block-poly (propylene glycol)-block-poly(ethylene glycol) (PEG- b -PPG- b -PEG) with average molecular weights of 12,000 and 8000 were purchased from Shanghai Energy Chemical Co., Ltd. and Aladdin Co., Ltd. Dimethyl sulfoxide (DMSO) was purchased from Shanghai Aladdin Biochemical Technology Co., Ltd. Acetonitrile and Trifluoroacetic acid were purchased from Shanghai J&K Scientific Ltd. Rotigotine was purchased from Shanghai yuanye Bio-Technology Co., Ltd. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) hydrochloride was obtained from Dalian Meilun Biotech Co., Ltd. Phosphate buffer saline (0.01M, pH 7.2–7.4) was purchased from Solarbio Biotech.

Techniques: Polymer, Concentration Assay, Molecular Weight

Synthesis and characterization of RT-NPs. (a) TEM image and (b) size distribution histogram of RT-NPs. (c) Hydrodynamic size distribution profile of RT-NPs. (d) UV–Vis-NIR absorbance spectra of rotigotine and RT-NPs. (e) Hydrodynamic size and (f) UV–Vis-NIR absorbance spectra of RT-NPs in aqueous solution recorded against time.

Journal: Fundamental Research

Article Title: Intranasal delivery of rotigotine to the brain for treating Parkinson’s disease

doi: 10.1016/j.fmre.2025.02.004

Figure Lengend Snippet: Synthesis and characterization of RT-NPs. (a) TEM image and (b) size distribution histogram of RT-NPs. (c) Hydrodynamic size distribution profile of RT-NPs. (d) UV–Vis-NIR absorbance spectra of rotigotine and RT-NPs. (e) Hydrodynamic size and (f) UV–Vis-NIR absorbance spectra of RT-NPs in aqueous solution recorded against time.

Article Snippet: Dichloromethane was purchased from Chinasun Specialty Products Co., Ltd. Poly (ethylene glycol)-block-poly (propylene glycol)-block-poly(ethylene glycol) (PEG- b -PPG- b -PEG) with average molecular weights of 12,000 and 8000 were purchased from Shanghai Energy Chemical Co., Ltd. and Aladdin Co., Ltd. Dimethyl sulfoxide (DMSO) was purchased from Shanghai Aladdin Biochemical Technology Co., Ltd. Acetonitrile and Trifluoroacetic acid were purchased from Shanghai J&K Scientific Ltd. Rotigotine was purchased from Shanghai yuanye Bio-Technology Co., Ltd. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) hydrochloride was obtained from Dalian Meilun Biotech Co., Ltd. Phosphate buffer saline (0.01M, pH 7.2–7.4) was purchased from Solarbio Biotech.

Techniques:

The flow diagram of selecting Rotigotine-related AEs from FAERS database

Journal: BMC Pharmacology & Toxicology

Article Title: Rotigotine safety in real-world settings: a pharmacovigilance study using FAERS data

doi: 10.1186/s40360-025-00911-5

Figure Lengend Snippet: The flow diagram of selecting Rotigotine-related AEs from FAERS database

Article Snippet: Concurrently, in a German clinical trial assessing the efficacy and tolerability of rotigotine for treating RLS led by Karin Stiasny-Kolster et al., a total of 84 skin reactions were documented among 66 (9.6%) of the patients.

Techniques:

Clinical characteristics of reports with  rotigotine  from the FAERS database

Journal: BMC Pharmacology & Toxicology

Article Title: Rotigotine safety in real-world settings: a pharmacovigilance study using FAERS data

doi: 10.1186/s40360-025-00911-5

Figure Lengend Snippet: Clinical characteristics of reports with rotigotine from the FAERS database

Article Snippet: Concurrently, in a German clinical trial assessing the efficacy and tolerability of rotigotine for treating RLS led by Karin Stiasny-Kolster et al., a total of 84 skin reactions were documented among 66 (9.6%) of the patients.

Techniques:

Time to onset of  Rotigotine-associated  adverse events and Weibull distribution analysis

Journal: BMC Pharmacology & Toxicology

Article Title: Rotigotine safety in real-world settings: a pharmacovigilance study using FAERS data

doi: 10.1186/s40360-025-00911-5

Figure Lengend Snippet: Time to onset of Rotigotine-associated adverse events and Weibull distribution analysis

Article Snippet: Concurrently, in a German clinical trial assessing the efficacy and tolerability of rotigotine for treating RLS led by Karin Stiasny-Kolster et al., a total of 84 skin reactions were documented among 66 (9.6%) of the patients.

Techniques:

The signal strength of AEs related to  rotigotine  at the SOC level in the FAERS database was detected by four algorithms

Journal: BMC Pharmacology & Toxicology

Article Title: Rotigotine safety in real-world settings: a pharmacovigilance study using FAERS data

doi: 10.1186/s40360-025-00911-5

Figure Lengend Snippet: The signal strength of AEs related to rotigotine at the SOC level in the FAERS database was detected by four algorithms

Article Snippet: Concurrently, in a German clinical trial assessing the efficacy and tolerability of rotigotine for treating RLS led by Karin Stiasny-Kolster et al., a total of 84 skin reactions were documented among 66 (9.6%) of the patients.

Techniques:

Signal Strength of top20 AEs of Rotigotine at the PT Level in FAERS Database

Journal: BMC Pharmacology & Toxicology

Article Title: Rotigotine safety in real-world settings: a pharmacovigilance study using FAERS data

doi: 10.1186/s40360-025-00911-5

Figure Lengend Snippet: Signal Strength of top20 AEs of Rotigotine at the PT Level in FAERS Database

Article Snippet: Concurrently, in a German clinical trial assessing the efficacy and tolerability of rotigotine for treating RLS led by Karin Stiasny-Kolster et al., a total of 84 skin reactions were documented among 66 (9.6%) of the patients.

Techniques:

The top 30 most frequent adverse events for  rotigotine  excluding common medication co-usage at the PT level from FAERS data

Journal: BMC Pharmacology & Toxicology

Article Title: Rotigotine safety in real-world settings: a pharmacovigilance study using FAERS data

doi: 10.1186/s40360-025-00911-5

Figure Lengend Snippet: The top 30 most frequent adverse events for rotigotine excluding common medication co-usage at the PT level from FAERS data

Article Snippet: Concurrently, in a German clinical trial assessing the efficacy and tolerability of rotigotine for treating RLS led by Karin Stiasny-Kolster et al., a total of 84 skin reactions were documented among 66 (9.6%) of the patients.

Techniques:

The top 30 signal strength of adverse events of  rotigotine  ranked by the number of case reports at the PTs level in FAERS database

Journal: BMC Pharmacology & Toxicology

Article Title: Rotigotine safety in real-world settings: a pharmacovigilance study using FAERS data

doi: 10.1186/s40360-025-00911-5

Figure Lengend Snippet: The top 30 signal strength of adverse events of rotigotine ranked by the number of case reports at the PTs level in FAERS database

Article Snippet: Concurrently, in a German clinical trial assessing the efficacy and tolerability of rotigotine for treating RLS led by Karin Stiasny-Kolster et al., a total of 84 skin reactions were documented among 66 (9.6%) of the patients.

Techniques: